Distribution of polymorphism rs693 of ApoB gene in a sample of Colombian Caribbeans / Distribución del polimorfismo rs693 en el gen de la apolipoproteína B en una muestra caribeños colombianos

Abstract Introduction: Several studies have reported that the single nucleotide polymorphism rs693 of Apo lipoprotein B gene is associated with high levels of plasma lipids and high body mass index, which are risk factors for cardiovascular diseases. The distribution of this single nucleotide polymorphism and its association with the phenotype depend on the genetic background of each population. Objective: To evaluate the distribution of single nucleotide polymorphism rs693 and its association with lipid profile and body mass index in a sample of Colombian Caribbeans. Methods: 108 non-related adult subjects of both gender were included in this study. Body mass index and lipid profile that included total cholesterol, triglycerides, Low Density Lipoprotein and High Density Lipoprotein were determined. The single nucleotide polymorphism rs693 was determined by Polymerase Chain Reaction/Restriction Fragment Length Polymorphism from genomic DNA followed by digestion with the restriction enzyme XbaI. The chi-square test was used to analyze the genotype distribution of rs693 and the genotype-phenotype association was evaluated through different inheritance model. Results: The genotype frequencies for single nucleotide polymorphism rs693 were CC (45.0%), TT (16.5%) and CT (38.5%). The allele frequencies were C (64.0%) and T (36.0%). The single nucleotide polymorphism was in Hardy-Weinberg equilibrium in the studied sample. No association of the single nucleotide polymorphism rs693 with lipid profile nor the body mass index was found (p >0.05). Conclusion: There is no significant association between single nucleotide polymorphism rs693 and body mass index nor lipid profile, in a sample of Colombian Caribbeans.

Resumen Introducción: Varios estudios han informado que el polimorfismo de un solo nucleótido rs693 del gen de la apolipoproteína B se asocia con altos niveles de lípidos plasmáticos e índice de masa corporal, los cuales son factores de riesgo para enfermedades cardiovasculares. La distribución de este polimorfismo y su asociación con el fenotipo dependen del antecedente genético de cada población. La población caribeña colombiana es producto de la mezcla de tres grupos étnicos principales: africano, amerindio y caucásico. Objetivo: Evaluar la distribución del polimorfismo rs693 y su asociación con el perfil lipídico y el índice de masa corporal en una muestra de sujetos caribeños colombianos. Métodos: Fueron incluidos en este estudio 108 sujetos adultos de ambos sexos y no relacionados. Se determinaron el índice de masa corporal y el perfil lipídico; de éste se incluyó colesterol total, triglicéridos, lipoproteínas de baja densidad y lipoproteína de alta densidad. El polimorfismo rs693 se determinó mediante Reacción en Cadena de la Polimerasa del ADN genómico seguida por digestión con la enzima de restricción XbaI. Se utilizó la prueba de ji cuadrado para analizar la distribución del genotipo de rs693 y se evaluó la asociación genotipo-fenotipo a través de diferentes modelos de herencia. Resultados: Las frecuencias genotípicas para rs693 fueron CC (45.0%), TT (16.5%) y TC (38.5%). Las frecuencias alélicas fueron C (64.0%) y T (36.0%). El polimorfismo rs693 estaba en equilibrio de Hardy-Weinberg en la muestra estudiada y no presentó asociación con el perfil lipídico ni con el índice de masa corporal (p >0.05). Conclusión: No existe asociación significativa del polimorfismo rs693 con el índice de masa corporal ni con el perfil lipídico en una muestra de caribeños colombianos.

Plan de salud para la juventud afrodescendiente de américa Latina y el caribe / Health Plan for Afro-Descendant Youth in Latin America and the Caribbean

El Plan de Salud para Jóvenes Afrodescendientes surgió de los esfuerzos de la Organización Panamericana de la Salud (OPS) crear oportunidades de diálogo que promuevan y faciliten la participación social en acciones relacionadas con la salud y el bienestar de los diferentes grupos étnicos que comparten la Región de las Américas, a lo largo de las diferentes etapas del curso de vida

The Health Plan for Afro-descendant Youth emerged from the efforts of the Pan American Health Organization (PAHO) to create opportunities for dialogue that promote and facilitate social participation in actions related to the health and wellbeing of the different ethnic groups that share the Region of the Americas, throughout the different stages of the life course

Plan de Salud para la Juventud Indígena de América Latina y el Caribe / Health Plan for Indigenous Youth in Latin America and the Caribbean / Plano de saúde para a juventude indígena da América Latina e do Caribe

Este Plan de Salud para Jóvenes Indígenas es producto del apoyo de la OPS a la creación de oportunidades de diálogo y participación social en acciones relacionadas con la salud que benefician a los jóvenes indígenas en América Latina y el Caribe.

This Health Plan for Indigenous Youth is a product of PAHO's support for the creation of opportunities for dialogue and social participation in health-related actions that benefit indigenous youth in Latin America and the Caribbean.

Este Plano de Saúde para Jovens Indígenas é um produto do apoio da OPAS para a criação de oportunidades de diálogo e participação social em ações relacionadas à saúde que beneficiam jovens indígenas na América Latina e no Caribe

Estimativas dos efeitos dos determinantes do aleitamento materno em inquéritos na América Latina e Caribe / Estimates of the effects of determinants of breastfeeding on surveys in Latin America and the Caribbean

Introdução-O aleitamento materno promove vantagens para a criança, mulher e sociedade. Entretanto as taxas de amamentação, principalmente o aleitamento materno exclusivo estão abaixo dos níveis desejados em diversos países. A identificação dos determinantes da interrupção precoce e a quantificação da interação destes fatores é crucial para estabelecer, avaliar e promover políticas públicas em prol das práticas de amamentação. Objetivo-Estimar os efeitos dos fatores associados à prevalência do aleitamento materno exclusivo, predominante e continuado no primeiro e segundo anos de vida em países da América Latina e Caribe no período de 2000 a 2016. Métodos-Foram utilizados microdados coletados no projeto Monitoring and Evaluation to Assess and Use Results Demographic and Health Survey. Para complementar as informações foram recolhidos dados agregados do World Bank. Os indicadores analisados foram aleitamento materno exclusivo (AME), aleitamento materno predominante (AMP) e aleitamento materno continuado (AMC) no primeiro e segundo anos de vida; os valores foram expressos em prevalência e estratificados por quintos de riqueza. Selecionou-se o último inquérito disponível de cada país da América Latina e Caribe com dados entre os anos de 2000 e 2016. As variáveis foram selecionadas segundo disponibilidade e enquadramento no modelo conceitual proposto por ROLLINS et al. (2016). O modelo utilizado no estudo foi elegido após análise com Regressão de Poisson e, posteriormente, foi realizada análise logística multinível de efeitos mistos para quantificar o efeito de cada determinante do efeito fixo ajustado pelo efeito randômico. Resultados-A variação das prevalências dos indicadores foi de 7,4% a 60,3% no AME, 13,9% a 71% no AMP, 35,0% a 86,6%no AMC no primeiro ano e 18,9% a 55,0% no AMC no segundo ano de vida. Bolívia e Guatemala se destacam por apresentar as maiores taxas de AME, 60,3% e 54,2%, respectivamente. Os países apresentaram maior prevalência dos indicadores nos quintos inferiores de renda, destacando-se as associações do padrão de aumento da magnitude do efeito negativo à medida que o quinto de renda aumenta. O AME e AMP se associaram diretamente à "amamentação na primeira hora", "estado conjugal" e "queria o último filho; "idade materna" e "status de trabalho" se associaram inversamente aos indicadores AMC no 1º e 2º anos de vida. Na análise de efeitos mistos, os indicadores AME e AMP se associaram diretamente a "amamentação na primeira hora" e "estado conjugal" e inversamente às variáveis "local do parto" e "status de trabalho". A escolaridade materna apresentou associação inversa com os indicadores AMP, AMC no 1º e 2º anos de vida e o quinto de riqueza apresentou associação inversa com todos os indicadores estudados. O AME apresenta maior variância explicada pelo nível individual, enquanto o AMC no 2º ano de vida sofre grande influência pelo nível contextual (8,99e-15% e 69,7%, respectivamente). Conclusão-As variáveis relacionadas ao indivíduo foram as que melhor explicaram a variância do modelo para o AME, AMP e AMC no 1º ano de vida. As variáveis relacionadas ao contexto explicam maior variabilidade da prevalência do AMC no 2º ano de vida, exibindo a maior interferência do PIB e de influências de âmbito nacional

Introduction-Breastfeeding promotes benefits for the child, woman and society. However, breastfeeding rates, especially exclusive breastfeeding, are below desired levels in many countries. The identification of the determinants of the interruption precociated and the quantification of interaction factors are crucial to establish, evaluate and promote public policies in breastfeeding practices. Objective-Estimate the effects of factors associated with the prevalence of exclusive, predominant and continued breastfeeding in the first and second years of life in Latin American and Caribbean countries from 2000 to 2016.Methods- We used microdata collected in the project Monitoring and Evaluation to Assess and Use Results Demographic and Health Survey. In addition to the information, aggregated World Bank data was collected. The indicators analyzed were exclusive breastfeeding (EB), predominant breastfeeding (PB) and continuous breastfeeding (CB) in the first and second years of life; the values were expressed in prevalence and stratified by quintiles of wealth. The last available survey of each Latin American and Caribbean country with data between the years 2000 and 2016 was selected. The variables were selected according to availability and framing in the conceptual model proposed by ROLLINS et. al. (2016). The model used in the study was chosen after analysis with Poisson Regression and later, multi-level mixed-effects logistic analysis was performed to quantify the effect of each determinant of the fixed effect adjusted by the random effect. Results- The prevalence of indicators ranged from 7.4% to 60.3% EB, 13.9% to 71% in PB, 35.0% to 86.6% in CB in the first year, and 18.9% to 55.0% in CB in the second year of life. Bolivia and Guatemala stand out for having the highest rates of EB, 60.3% and 54.2%, respectively. The countries presented a higher prevalence of indicators in the lower quintiles of income, especially the associations of the pattern of increase of the magnitude of the negative effect as the fifth of income increases. EB and PB were directly associated with "first-time breastfeeding", "marital status" and "wanted the last child; "maternal age" and "work status" were inversely associated with the CB indicators in the 1st and 2nd years of life. In the mixed effects analysis, the EB and PB indicators were directly associated with "first-hour breastfeeding" and "marital status" and inversely to the variables "place of birth" and "work status".The maternal schooling presented an inverse association with the PB, CB indicators in the 1st and 2nd years of life, and the fifth of the wealth had an inverse association with all the indicators studied. The EB shows greater variance explained by the individual level, while the CB in the second year of life suffers great influence at the contextual level (8.99e-15% and 69.7%, respectively). Conclusion- The variables related to the individual were the ones that best explained the variance of the model for EB, PB and CB in the 1st year of life. The variables related to the context explain a greater variability of the prevalence of CB in the second year of life, showing the greater interference of GDP and national influences

Plan de salud para la juventud indígena de América Latina y el Caribe 2017 / Health plan for indigenous youth in Latin America and the Caribbean 2017

América Latina y el Caribe es una de las regiones más diversas del mundo. Al mismo tiempo, es una región en donde se evidencian las mayores disparidades socio-económicas en términos de clase. La OPS reconoce la necesidad de hacer frente a las diversidades étnicas, sociales y culturales que existen a lo interno de los Estados Miembros y las unidades técnicas para crear políticas y servicios de salud accesibles a poblaciones enteras. Existe una amplia evidencia sobre las desventajas y discriminación que los hombres y especialmente las mujeres de estas poblaciones experimentan con respecto a su bienestar. Los sistemas de información en salud también fallan al momento de reconocer las particularidades y necesidades de estos grupos, lo cual afecta la propia definición de intervenciones e indicadores que buscan evaluar la efectividad en el mejoramiento de la salud de estas poblaciones. El proceso de formulación, implementación, seguimiento y evaluación de las políticas públicas debe asegurar la participación de las poblaciones involucradas, el respeto de los derechos humanos, la interculturalidad y la igualdad de género.

Diseño de un sistema de vigilancia epidemiológica para los XVII Juegos Deportivos Centroamericanos y del Caribe, Puerto Rico, 1993 / Development of a system for epidemiologic surveillance for the XVII Central American and Caribbean Sport Games, Puerto Rico, 1993

The probability of recording infectious diseases and injuries to the musculoskeletal system during sports events with a large number of participants is very high. From an historical perspective the distribution and trends of diseases that have an impact on public health have been evaluated by means of epidemiological surveillance systems. However, the application of these epidemiological methods to sports medicine is relatively recent. The utilization of an epidemiological surveillance system during sports events with a large number of participating athletes and countries has been reported in a limited number of competitions. In this article we describe the design of a system for epidemiological surveillance utilized during the XVII Central American and Caribbean Sports Games held in Puerto Rico in 1993, as an example of a surveillance system that could be regularly established in this type of event

Descripción de la morbilidad reportada en el sistema de vigilancia epidemiológica de los XVII Juegos Deportivos Centroamericanos y del Caribe, Puerto Rico, 1993 / Description of morbidity notified in the epidemiologic surveillance system of XVII Central American and Caribbean Sport Games, Puerto Rico, 1993

The objective of the epidemiological surveillance system for the XVII Central American and Caribbean Sports Games in 1993 in Puerto Rico was to estimate the morbidity related to infectious diseases and sports injuries during the competitions. In the village hospital a total of 794 medical consultations were reported; 57.7 per cent of the patients were athletes. Among athletes, the rate of consultation was 10.4 for every 100 participants. The consultations were more frequent in males (535, 67.4 per cent ). The analysis by country of origin revealed that the athletes from Guatemala (42, 9.2 per cent ) and Jamaica (35, 7.6 per cent ) used the services more frequently. The incidence of consultations by sport was higher in field hockey (47, 10.3 per cent ), followed by athletics (46, 10 per cent ), and softball (36, 7.9 per cent ). The most frequent diagnoses were injuries--302, 38.04 per cent ; of these 229 (75.8 per cent ) were athletes--,conditions of the respiratory system (180, 22.67 per cent ), problems of the skin and mucous membranes (85, 10.71 per cent ), and problems of the gastrointestinal tract (56, 7.05 per cent ). The severity of the majority of the conditions was mild and required primary care health professionals